The unique potential of RBCs due to long half-life, biocompatibility, and large volume capacity has not been fully exploited in diagnostics and therapy. Red blood cells (RBCs) are natural carriers that can deform and squeeze through capillaries, and the immune system does not readily recognize them as foreign. Simberg, D., Complement Proteins Bind to Nanoparticle Protein Corona and Undergo Dynamic Exchange in Vivo. (2014) High-Relaxivity Superparamagnetic Iron Oxide Nanoworms with Decreased Immune Recognition and Long-Circulating Properties. (2013) Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. P., Mukthavaram, R., Kesari, S., Kouznetsova, V. (2009) Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance.
We are using biomimetic and synthetic approaches to design safe and efficient imaging and drug delivery carriers based on nanoworms for therapy and imaging of diseases. Recently we described in Nature Nanotechnology the mechanisms by which nanoworms activate complement via the alternative pathway. There is still insufficient knowledge of the basic mechanisms that lead to nanoparticle recognition and elimination.įunded by NIH R01 grant, we use SPIO in order to decipher the mechanisms of immune activation by nanoparticles, understand the consequences of complement activation, and to design synthetic strategies to mitigate complement activation by nanoparticles. This process is the major problem in nanomedicine since it decreases the dose of nanoparticles in the tumor, limits the efficiency of imaging and therapy, and causes toxicity. Intravenously injected nanomaterials undergo interactions with plasma components and immune receptors, with subsequent clearance by body macrophages and monocytes. Central Alumni Relations – Happy & Healthy Hour.Associate Dean of Research and Graduate Studies.
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